https://thatcherresearchgroup.com/blog daily 0.75 2025-10-20 https://thatcherresearchgroup.com/blog/2025-acdd-summit monthly 0.5 2025-10-20 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988561834-1DVK9YOHGLN5VK78I8RP/IMG_7835.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988545988-0WGK20V0WW4ZBK1WDPWZ/IMG_7823.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988555278-07GM13IR0L9F3XHGUQPC/IMG_7821.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988572111-BSUCU1RX1SMEQJDNOH2A/IMG_7832.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988566511-PR7CXJ58MT2MSEM5HWUT/IMG_7834.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988573880-C06AXG7FIPIKOBJS75KA/IMG_7883.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988546080-JMCDXRETVO015Z5WLZH1/IMG_7818.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988574098-U5PF2UO0UTEZUS7QD2HD/IMG_7824.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988554097-ROY6L9834FR52YF2VT91/IMG_7816.jpeg Blog - 2025 ACDD Summit https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1760988557008-JHBZW9GNNNWXHC53MTRX/IMG_7815.jpeg Blog - 2025 ACDD Summit https://thatcherresearchgroup.com/blog/celebration-and-holiday-party monthly 0.5 2025-01-09 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1736443798477-V4RB1NI56B84KCF1WB0V/EF3D0F50-68A2-4587-B3E2-F227FA306679.JPG Blog - Celebration and Holiday Party https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1736443796553-7920VRVTB4OG070MYRZN/IMG_0372.jpg Blog - Celebration and Holiday Party https://thatcherresearchgroup.com/blog/congrats-graduates monthly 0.5 2024-12-12 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1734037809743-O61AZZMQW4QIIQOUMPZ0/IMG_6621.jpeg Blog - Congrats Graduates! https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1734037807557-NVAQVS4W6IC43HHEQTWU/IMG_2120.jpeg Blog - Congrats Graduates! https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1734037930672-NDJR0CB5W5DYXDSQ1KJC/IMG_6620.jpg Blog - Congrats Graduates! https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1734037892953-AHV7D5TUS7I268L3212G/IMG_7264.jpg Blog - Congrats Graduates! https://thatcherresearchgroup.com/blog/group-lunch monthly 0.5 2024-11-13 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/16b3af72-fe0e-4c79-b2f5-586d5b731b8a/IMG_7888.jpg Blog - Group Lunch - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://thatcherresearchgroup.com/blog/wnrkbor5kaq6x5ei1pljg6w0k41lot monthly 0.5 2024-06-04 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531014411-42CHVDNTHME45JK9WPC6/ACA.jpg Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717538063449-7C4IXXSXZT780J169KOC/2B68CFE0-0920-48FA-BB1C-E64A0C221571.jpg Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717538048254-0GP7BECV1CEKIRIV1ED6/IMG_8780.jpg Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531051767-0W286BXUE1GXV3DMBE52/IMG_5556.JPG Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531055480-RDDGCMWGBPX1IPS3YL3R/IMG_5545.JPG Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531062308-OV0PDS99S7JPWCQL1HGB/IMG_1322.JPG Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531062901-B47ATCPZ3KV4J8X2M35R/294386B5-1E13-4514-A9FC-92AF1F0FD92C.jpeg Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531068264-AUCM02U72BGVXLLZLWTM/IMG_4900.jpg Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531061500-1BEA1Q8KF0KLF9N0EUSF/IMG_5542.JPG Blog - ACS Conference https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717531059079-8XPPJQC509V0LQEM73S7/IMG_0207.JPG Blog - ACS Conference https://thatcherresearchgroup.com/blog/outreach-event-with-paws monthly 0.5 2023-08-10 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691709733584-UV97X6XBVXKIO34AN0YC/IMG_4191.JPG Blog - Outreach Event with PAWS https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691709730604-4P7YPNYFXINJK19SL41G/paws+science+night+2.jpeg Blog - Outreach Event with PAWS https://thatcherresearchgroup.com/blog/ginny-l-clements-breast-cancer-research-institute-symposium monthly 0.5 2025-01-09 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691708236118-16GHSLIP6YU3TCKIZOI1/MicrosoftTeams-image+%282%29.png Blog - Ginny L. Clements Breast Cancer Research Institute Symposium https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691708237994-R5ASHZKOPPGIS1UDSF7P/MicrosoftTeams-image+%284%29.png Blog - Ginny L. Clements Breast Cancer Research Institute Symposium https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691708096861-8O636E0IGO63J4Y70ER5/IMG_4041.jpg Blog - Ginny L. Clements Breast Cancer Research Institute Symposium https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691708096110-XBNFIUXXPR0O3VV2960B/IMG_4037.jpg Blog - Ginny L. Clements Breast Cancer Research Institute Symposium https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1691708241361-TCI7X3M7F2CMZFP4B4Y9/processed-2128A9D5-3640-4800-8425-11A0027FD3CD-89F9AA34-2E76-41D5-9889-38245E57ACEC.jpeg.jpeg Blog - Ginny L. Clements Breast Cancer Research Institute Symposium https://thatcherresearchgroup.com/blog/happy-retirement monthly 0.5 2023-08-10 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/b2b81898-2b69-4dc4-8349-c0597860b949/IMG_6816.JPG Blog - Happy Retirement - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://thatcherresearchgroup.com/blog/thank-you-and-farewell monthly 0.5 2023-08-10 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/b91a8357-471f-486e-8383-28163086a12d/IMG_8011.jpg Blog - Thank you and farewell - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://thatcherresearchgroup.com/blog/holiday-party monthly 0.5 2023-08-10 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/63e76230-5ef9-4972-a23c-e8d508d578a9/IMG_6587.jpg Blog - Holiday Party - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://thatcherresearchgroup.com/blog/celebrations-of-the-new-year monthly 0.5 2023-08-10 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/0bff5433-1081-4715-9180-08661e3cbbe0/Screen+Shot+2023-02-07+at+9.55.27+PM.png Blog - Celebrations of the New Year! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://thatcherresearchgroup.com/blog/recent-successes monthly 0.5 2022-05-24 https://thatcherresearchgroup.com/blog/field-trip-to-the-worms monthly 0.5 2021-04-28 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1619637826298-L3J4J9ZL9Y22AZDJYPNG/MArtha+and+Thatcher.jpg Blog - Field Trip to the Worms This morning the group went on a field trip to one of our collaborators, George Sutphin’s, laboratory. His group uses C. elegans to study the molecular biology of aging. With these organism we hope to explore the possibility of incorporating them in the drug discovery process. It was an interesting time looking at the worms first hand and learning about the techniques used to conduct experiments. https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1619637832575-WB39MTXAHV9OPBCLLTR0/Chris_Worms.jpg Blog - Field Trip to the Worms https://thatcherresearchgroup.com/blog/new-website monthly 0.5 2021-04-26 https://thatcherresearchgroup.com/groupmembers daily 0.75 2026-02-05 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/4ae067a4-d11e-42bf-a5c4-0fda9b8b9a02/MarthaHeadshot.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/b9b0a119-78ab-4fdb-97e4-99fde3c4b1e8/stocktesttubes_website.jpeg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/5840c042-faad-418e-afe2-8a47926e910a/ZhengnanPlaceholder.jpeg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/f0221165-4500-44c7-b9d8-6cc12ca245fe/Jenna+Headshot.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/99d899fb-e6e9-4e1f-bc8a-7a5e3326f8dd/Farinaz+Headshot.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/d24d4984-70a6-4ee9-808d-b3092c0f08cf/GangaReddyWebsite.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/5dc1145d-5173-4859-9d8f-8006d533918b/image.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/4588d12e-a5f0-44fa-9ff7-91967ed5f353/20240604_124856.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1717532015878-FI43SVQ4YCQT0HZUHKXD/image-asset.jpeg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/398a3777-9877-41e2-a241-d28e0c155a6c/IMG-20240604-WA0014.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/baa26818-f657-4bd6-9d02-51af63b002ac/1705260648279.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/50fb860c-f14a-4d5f-b989-8286003461b9/Anandhan+Photo+2%5B87%5D.jpeg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/b6fff0a4-e603-42b3-a0b6-bf5b63075d7c/Juhaer-Anjum.png Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/13b1de80-d1e6-4fcd-a24c-5741d0b00c2a/1693429342255.jpg Group Members https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1615494492823-WKWS1QP5RQEHEYA4BGEZ/ThatcherHeadShot.jpg Group Members - Gregory Thatcher, PhD Professor, Pharmacology and Toxicology R. Ken and Donna Coit Endowed Chair in Drug Discovery Greg Thatcher, PhD, joined the University of Arizona in 2020 from the University of Illinois College of Pharmacy. In his career, he has graduated over 50 students with PhD’s and a dozen with MSc’s and mentored 40 undergraduate researchers, the majority of these undergrads while on faculty in the Chemistry Department at Queen's University in Canada from 1988 until 2002. These trainees have proceeded to positions in biotech, pharma, business, education, and academia in the USA, Canada, Europe, India, and China. While at the University of Illinois in Chicago (UIC), Thatcher acted as founder/leader of the Translational Oncology Program in the University of Illinois Cancer Center and co-director of the NIA Predoctoral Training Program in Alzheimer’s Disease & Related Dementia. In 2013, he founded a campus-wide and disease-agnostic drug discovery center at UIC, focused on small molecule drug discovery, which continues to play an active role in academic drug discovery across Chicago. Dr. Thatcher created his first start-up biotech company in 1997, which successfully took an Alzheimer’s drugs into human clinical trials. The Thatcher lab’s research has been continuously funded by the NIH since 2003, supported by NCI, NIA, NHLBI, NIAID, and NCCAM, resulting in over 170 publications and dozens of issued patents. Two new chemical entities were licensed and successfully completed Phase 1 clinical trials for metastatic breast cancer in 2019. https://thatcherresearchgroup.com/research daily 0.75 2021-12-08 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1638937203659-1JB37MRCKHD4AVUYIAWO/unsplash-image-hnqQESm6yAg.jpg Overview - Aging Compared to 1990, life expectancy has increased from 73 to almost 80 for women and from 67 to 73 years old for men in high income countries; whereas globally life expectancy is currently 76 for women and 71 for men. Healthy life expectancy globally is 65 and 62 for women and men, respectively. In one analysis, the number of years gained in the USA is split equally between years in poor health and years in good health. Aging is the greatest risk factor for Alzheimer’s disease and related dementia. In women, the number of years lost to ill-health caused by Alzheimer’s disease ranked #33 in 1990, #22 in 2007, and #15 in 2017. Although women live longer than men, half of that increased lifespan is spent in poor health. Human aging is extremely difficult to model in the lab, even without adding the complexity of human dementia and remembering that Alzheimer’s disease can only be definitely diagnosed post-mortem. https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1638937307170-XO4SK4MKOLLYGESOPZNX/unsplash-image-XknuBmnjbKg.jpg Overview - Cancer Cancer has been with mankind throughout recorded history. Cancer describes numerous human maladies characterized by reprogramming of our own human cells causing unregulated growth, either in the blood, or in tissues leading to solid tumors. In general, metastatic disease describes the progression and dispersal of the primary cancer or tumor cells to other organs. In the last century, natural products provided the backbone of cancer chemotherapy. These natural products were developed by organisms to kill other competitor organisms and this cytotoxicity was harnessed to kill cancer cells; however, cytotoxic chemotherapy has severe and unpleasant side effects. Targeted therapies that are generally not cytotoxic, but target specific vulnerabilities that are amplified in cancer cells, have had a significant impact in treating cancer. More recently, immuno-oncology has also had major impact. Nevertheless, resistance to therapy often leads to metastatic disease, needing new therapeutics. https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1638937336168-H8ET4FSXXUB008REGW1J/unsplash-image-FcDqdJUM6B4.jpg Overview - Anti-Infectives The COVID-19 pandemic has focused the thoughts of society on pathogens. These range from bacteria, fungi, and worms that are very much alive to viruses, the vitality of which is problematic. As in cancer chemotherapy, natural products, designed to kill competing organisms, have supplied our arsenal of anti-infective therapeutics; and as in cancer, resistance is an issue. Bacteria are studied as components of the microbiome, increasingly appreciated to contribute to human health and disease. Equally, the worm, C. elegans is allowing the study of aging and target identification for drugs directed at human diseases. Our disease-agnostic approach to drug discovery permits pivoting from using small molecules in breast cancer to re-engineering these molecules for Ebola antiviral therapy. https://thatcherresearchgroup.com/publications daily 0.75 2023-02-08 https://thatcherresearchgroup.com/contact-us daily 0.75 2024-11-13 https://thatcherresearchgroup.com/home-1 daily 1.0 2023-08-15 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1615491048773-MM5TGMMTO8XALH6B2RFH/UofA_stock.jpg Home (Copy) - University of Arizona, College of Pharmacy, Tucson, AZ https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1638937005001-U5QGNE8DJ8GH32VR55Y7/unsplash-image-pwcKF7L4-no.jpg Home (Copy) https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1638937070829-R2C5ULNP8K3X9TEEJBHD/unsplash-image-XN4T2PVUUgk.jpg Home (Copy) https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617757461917-92EVH80HQAMU15L3UB17/OldMain_Website.jpeg Home (Copy) https://thatcherresearchgroup.com/aging daily 0.75 2021-04-28 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617748599446-UDU51MWJ8S97ZFSJLMX2/Extending+Healthspan_website.jpg Aging https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617747892982-VFEFC82DB2ZVRBN00OYS/ABCA1_website.jpg Aging https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617743162587-HVAX5BEEN0V36WMX03C4/NAMPT_website.png Aging https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617748797444-UJJ8IFPVLFPWDFD9TVOG/NO+Honey_website.png Aging https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617748868610-I0NOFDMS3V5H1FESX8UL/ConventionAD.png Aging https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617749019437-X5BR6X7H7UG7IF9Y8TLU/WomenEstrogen_website.png Aging https://thatcherresearchgroup.com/cancer daily 0.75 2021-04-26 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617749392595-RBTWAXOD9QYTEE1BGXXF/ERBreastCancer2.png Cancer https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617749382774-Z6B24GMHQFGBAV1DVPAX/ERBreastCancer1.png Cancer https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617749583676-5XYM0TNJUIUJRPK2OLID/TacklingResistance_Website.png Cancer https://thatcherresearchgroup.com/antiinfective daily 0.75 2021-04-26 https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617749714513-3QQTKX7SZHPGCEQTWXBR/Anti-InfecticeDrug_website.png Anti-Infective https://images.squarespace-cdn.com/content/v1/6049333155fa64141c2a33f1/1617749793499-ILU10ZQF5Z6DW1T69O4W/OxidativeStress_website.png Anti-Infective